The Mosher Lab
Understanding small RNAs during seed development
"Somewhere, something incredible is waiting to be known."
Eukaryotes contain an array of small interfering (si)RNAs capable of transcriptional and post-transcriptional gene regulation. These ubiquitous molecules are part of many biological processes, including development, response to the environment, and disease. Originally identified in plants, siRNAs are now studied in diverse organisms and are an important tool in human therapeutics.
Our laboratory studies the synthesis and action of siRNAs associated with RNA-directed DNA Methylation, with particular emphasis on seed development. We combine traditional genetics with comparative genomics and phylogenetic analysis in a variety of plant systems.